Introduction to Elemental Microanalysis
Elemental microanalysis is a crucial technique used in various scientific and industrial applications, ranging from pharmaceuticals to environmental testing. At Butterworth Laboratories, we harness cutting-edge technology to deliver precise and reliable microanalysis services, ensuring high-quality data for our clients.
What is Elemental Microanalysis?
Elemental microanalysis entails the determination of the elemental composition of a sample, focusing on key elements such as Carbon (C), Hydrogen (H), and Nitrogen (N), using small sample aliquots (<5mg). Some instruments also enable the analysis of Sulfur (S) and Oxygen (O).
The technique is used for determining the empirical formulae of novel research compounds. It can also be applied to determining Organic Carbon in Sediments, following the removal of Inorganic Carbon with Hydrochloric or sulfurous acid. Analysis of these elements in organic and organometallic compounds is integral to understanding material properties, formulation quality, and compliance with regulatory standards.
The Role of CHN Analysers
At the heart of our elemental microanalysis services is the CHN analyser. This sophisticated instrument allows us to:
Ensure High Sensitivity and Accuracy: With advanced detection methods, our CHN analyser can analyse low-concentration elements, making it suitable for both trace analysis and bulk material testing.
Accurately Measure Elemental Content: Our CHN analyser provides precise quantification of carbon, hydrogen, and nitrogen in solid and liquid samples, essential for various research and quality control applications.
Enhance Sample Throughput: The automated capabilities of our CHN analyser enable rapid sequencing and analysis of multiple samples, thereby increasing efficiency and reducing turnaround times.
Applications of Elemental Microanalysis
Elemental microanalysis using a CHN analyser finds applications in a broad range of fields, including:
- Pharmaceutical Development: Evaluating purity and composition of compounds, critical for drug formulation and regulatory compliance.
- Environmental Monitoring: Analysing sediment samples to assess contamination and environmental health.
- Material Science: Determining the composition of polymers, and other materials to study their properties and behaviors.
Royal Society of Chemistry (RSC)
Over the years, Butterworth staff have been involved with the oldest of the RSC’s Interest Groups, the Microanalytical Group. Click here for more details.
Learn how Elemental Microanalysis testing is applied across industries.
Frequently Asked Questions (FAQs)
Elemental microanalysis is suitable for a wide variety of sample types, including organic compounds, organometallic materials, polymers, pharmaceuticals, and environmental samples such as sediments. Only a small amount of sample (typically less than 5 mg) is required, making the technique ideal for both research and quality control applications where material may be limited.
CHN analysis provides highly accurate and reproducible measurements of carbon, hydrogen, and nitrogen content, with precision typically within ±0.3% absolute. When extended to include sulfur and oxygen determination, the technique provides a comprehensive elemental profile, enabling precise empirical formula calculations and purity assessments.
In pharmaceutical development, elemental microanalysis is vital for verifying the composition and purity of active pharmaceutical ingredients (APIs) and intermediates. Accurate CHN data confirm that a compound’s structure matches its theoretical formulation and complies with regulatory requirements. It also helps detect impurities or deviations that could affect drug efficacy or safety.
Butterworth Laboratories operates under strict quality assurance systems, including UKAS Accreditation and compliance with Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) standards. With over 50 years of expertise in elemental microanalysis, our laboratory ensures data integrity, traceability, and reliability for every analysis performed.
Why Choose Butterworth Laboratories?
Choosing Butterworth Laboratories for your elemental microanalysis needs ensures that you receive:
- Expert Analytical Services: Our team of skilled professionals is dedicated to delivering high-quality, accurate results tailored to your specific requirements. The company was founded in 1974 to provide Elemental Microanalysis services, so we have over 50 years of experience in the technique.
- Commitment to Quality: We adhere to strict quality control measures, ensuring data integrity and compliance with industry standards. The test is not only UKAS Accredited, but has been used in GLP Studies over the years.
