The importance of nitrosamines and recent developments in analysis

Interest in nitrosamine testing increased sharply following the discovery of nitrosamine impurities in pharmaceutical products, including Sartan medicines, in 2018. Early analytical procedures had relied mainly on chemical reactions and spectrophotometric methods, which could indicate the presence of nitroso compounds but lacked the required specificity and sensitivity for targeted quantitation. However, analysis has evolved from these relatively simple chemical detection methods into highly sensitive, selective techniques capable of measuring trace concentrations of specific targets in complex sample matrices.

To read the full article written by Frank Judge, Consultant Chemist, and published by Manufacturing Chemist: Click Here

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