Elemental microanalysis testing is an essential technique for determining the elemental composition of a wide range of materials. From pharmaceuticals and polymers to catalysts, metals, and environmental samples. Our advanced microanalysis solutions deliver rapid, accurate, and reliable results, enabling researchers and manufacturers to ensure product quality, verify molecular structures, and meet stringent regulatory requirements. Whether you’re conducting routine quality control or cutting-edge materials research, our application expertise and state-of-the-art instrumentation help you achieve unmatched analytical confidence and precision.
Carbon, Hydrogen and Nitrogen Analysis
For over 50 years, the heart of our elemental microanalysis services has been the CHN analyser. The CE440 CHN Elemental Analyser, with its unique horizontal furnace, is known for its accuracy and precision, which is why it is widely regarded as the industry standard for CHN analysis.
Oxygen Flask Combustion
Alongside this, we also offer the Oxygen Flask Combustion, using the Schöniger flask method, for measuring Sulphur, Phosphorus and Halogens (F, Cl, Br, I). Following the Oxygen Combustion, a variety of techniques, including Titrimetric Analysis, Ion Chromatography and ICP-MS.
Importance of Elemental Microanalysis in Pharmaceutical Testing
Elemental microanalysis plays a critical role in the pharmaceutical industry by ensuring the safety, efficacy, and quality of drug products. Precise determination of elemental composition verifies that active pharmaceutical ingredients (APIs) and excipients meet strict purity specifications and conform to their intended molecular structures. This analysis is essential for detecting trace elements, residual catalysts, and potential contaminants that may affect drug stability or pose toxicological risks. Furthermore, compliance with international guidelines, such as ICH Q3D for elemental impurities, requires accurate elemental quantification throughout development and production. By providing reliable, reproducible data, elemental microanalysis supports regulatory compliance, product consistency, and the overall integrity of pharmaceutical research and manufacturing. To learn how we perform this technique in the lab, visit our Elemental Microanalysis Techniques page.
Frequently Asked Questions (FAQs)
It helps confirm the empirical formula of drug substances and supports regulatory submissions by verifying elemental composition.
We analyse active pharmaceutical ingredients (APIs), excipients, agrochemicals, polymers, and a wide range of industrial compounds.
Yes. Our results comply with ICH and EMA requirements and can be included in quality dossiers and marketing authorisation applications.
Turnaround depends on the sample type and the number of tests required. Please contact us to receive an estimated lead time tailored to your specific project.
While it offers high sensitivity, trace-level detection depends on the specific element and matrix. We can advise based on your material.
Why Choose Butterworth Laboratories?
- Over 50 years of independent contract analytical experience in the pharmaceutical and related industries.
- Expertise with small-sample analysis — accurate results from milligram material
- Integrated techniques: from classical combustion to ICP-MS and ion chromatography
- Clear reporting, method documentation, and open communication with scientists
